Professor Andrew Jamieson

  • Professor of Chemical Biology (School of Chemistry)

telephone: 07970818676
email: Andrew.Jamieson.2@glasgow.ac.uk

Office 466, Mazumdar-Shaw Advanced Research Centre (ARC), 11 Chapel Lane, University of Glasgow, G11 6EW

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1726-7353

Biography

Andrew Jamieson was born in Glasgow and raised in Strathaven, Scotland. 

In 2003, he completed a BSc Honours degree (1st Class) in Chemistry with Medicinal Chemistry at the University of Glasgow.

He subsequently studied for a Ph.D. at the University of Glasgow under the supervision of Dr Andrew Sutherland. The aim of his Ph.D. was to investigate a new substrate directed, palladium-catalysed aza-Claisen rearrangement, and utilise this novel reaction for the synthesis of natural products.

In 2007, he took up a postdoctoral research fellowship with Professor William Lubell at the University of Montreal, Canada. During this time he developed a novel synthetic method with which to systematically scan peptides for secondary structure. His research emphasis was determining the bioactive conformation of the growth hormone secretagogue, GHRP-6, as well as the allosteric modulator of the IL-1 receptor, 101.10 (rytvela).

In 2008, he took up a postdoctoral position with Professor Andrew Hamilton FRS at Yale University, USA. While there he worked on the design and synthesis of a novel peptide beta-strand mimetic, before moving with Professor Hamilton in 2009 to the University of Oxford, UK.

In August 2010, he was appointed to a lectureship in the Centre for Chemical Biology in the Department of Chemistry at the University of Leicester, UK.

He was then appointed as a senior lecturer in Chemical Biology at the University of Glasgow School of Chemistry in July 2016. He currently runs a research group whose work focuses on the synthesis of peptides and peptidomimetics that can be used to probe the biological mechanisms of cancer and Alzheimer’s disease.

Andrew’s main hobbies outside of chemical biology are running, rugby and snowboarding.

Research interests

A PhD studentship is currently available to work in the group developing a new peptidomimetic. For further details, please follow the link.

 

Research in the Jamieson Group is focused on the design and synthesis of peptides and peptidomimetics that can be used to probe the biological mechanisms underpinning disease. The information obtained from these studies is then used to inform the development of precision medicines.

We are particularly interested in the selective regulation of ion-channels by conotoxins with potential application in the treatment of severe pain. We are also investigating the structural activation and substrate binding of deubiquitinase (DUB) and histone deacetylase (HDAC) enzymes and developing novel peptide based inhibitors. We are also attempting to determine the structure of toxic amyloid proteins that are proposed to be the underlying cause of Alzheimer’s disease.

Selected publications

  1. P. J. Watson, C. J. Millard, A. M. Riley, N. S. Robertson, L. C. Wright, H. Y. Godage, S. M. Cowley, A. G. Jamieson, B. V. L. Potter, John W. R.  Schwabe, The mechanism of activation of class I HDAC complexes by inositol phosphates. Nat. Commun., 2016, 7, 11262 (DOI: 10.1038/ncomms11262)
  2. M. J. Burton, S. M. Kapetanaki, R. C. Stratton, A. G. Jamieson, N. W. Davies, J. S. Mitcheson, R. Schmid, P. C. E. Moody, E. L. Raven, N. M. Storey, Heme modulates cardiac KATP channel function., PNAS, 2016, 113, 3785–3790.
  3. N. Allaway, A. G. Jamieson, Regulation of Protein-Protein Interactions using Stapled Peptides. Rep. Org Chem., 2015, 5, 65 - 74.
  4. B. Aillard, N. S. Robertson, A. R. Baldwin, S. Robins, A. G. Jamieson, Robust Asymmetric Synthesis of Unnatural Alkenyl Amino Acids for Conformationally Constrained alpha-Helix Peptides. Org. Biomol. Chem., 2014, 12, 8775.

 

Selected Recent Talks

“Next Generation Histone Deacetylase Inhibitors: Structure-Based Design of Peptide Mimetics” 50th European Symposium on Biological and Organic Chemistry, Gregynog, Newtown, Wales, May 2016 

“Peptide Tools for Chemical Biology and Drug Discovery”, Sygnature Discovery, Nottingham, May 2016

“Regulation of HDAC-Corepressor PPIs: Towards Next Generation HDAC inhibitors”, EPSRC Programme Grant on PPIs Launch Event, University of Leeds, May 2016

“Conformationally-Constrained alpha-Helix Peptides: New Tools for Chemical Biology and Drug Discovery”, Defense Science and Technology Laboratory (DSTL), Porton Down, Salisbury, September 2015.

 

External Appointments & Positions

EPSRC College and Panel Member

Member of the SCI Industry Young Chemists Panel

Member of the RSC Chemical Biology and Bioorganic Group Committee

Member of the L'Agence Nationale de la Recherche (ANR) Grant Review Panel

 

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2004
Number of items: 48.

2024

Brettell, S. B. et al. (2024) Targeting PfCLK3 with covalent inhibitors: a novel strategy for malaria treatment. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01300) (PMID:39441986) (Early Online Publication)

2023

McGrory, R., Morgan, D. C., Jamieson, A. G. and Sutherland, A. (2023) Rotamer-controlled dual emissive α-amino acids. Organic Letters, 25(31), pp. 5844-5849. (doi: 10.1021/acs.orglett.3c02112) (PMID:37506290) (PMCID:PMC10425982)

Morgan, D. C., McDougall, L., Knuhtsen, A. and Jamieson, A. G. (2023) Development of bifunctional, Raman active diyne‐girder stapled α‐helical peptides. Chemistry: A European Journal, 29(41), e202300855. (doi: 10.1002/chem.202300855) (PMID:37130830)

2022

Archibald, L. J., Brown, E. A., Millard, C. J., Watson, P. J., Robertson, N. S., Wang, S., Schwabe, J. W. R. and Jamieson, A. G. (2022) Hydroxamic acid-modified peptide library provides insights into the molecular basis for the substrate selectivity of HDAC corepressor complexes. ACS Chemical Biology, 17(9), pp. 2572-2582. (doi: 10.1021/acschembio.2c00510) (PMID:35973051) (PMCID:PMC9488896)

Mahindra, A. et al. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists. Journal of Medicinal Chemistry, 65(16), pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804) (PMID:35948061) (PMCID:PMC9421653)

Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)

2021

Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)

Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)

Knuhtsen, A., Whiting, R., McWhinnie, F. S., Whitmore, C., Smith, B. O. , Green, A. C., Timperley, C. M., Kinnear, K. I. and Jamieson, A. G. (2021) μ-conotoxin KIIIA peptidomimetics that block human voltage-gated sodium channels. Peptide Science, 113(1), e24203. (doi: 10.1002/pep2.24203)

2020

Mahindra, A., Janha, O., Mapesa, K., Sanchez Azqueta, A., Alam, M. M. , Amambua-Ngwa, A., Nwakanma, D. C., Tobin, A. B. and Jamieson, A. G. (2020) Development of potent PfCLK3 inhibitors based on TCMDC-135051 as a new class of antimalarials. Journal of Medicinal Chemistry, 63(17), pp. 9300-9315. (doi: 10.1021/acs.jmedchem.0c00451) (PMID:32787140) (PMCID:PMC7497403)

Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G. and Di Antonio, M. (2020) A short peptide that preferentially binds c-MYC G-quadruplex DNA. Chemical Communications, 56(63), pp. 8940-8943. (doi: 10.1039/D0CC02954H) (PMID:32638724)

Magnussen, H. M. et al. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications, 11, 2094. (doi: 10.1038/s41467-020-15783-y) (PMID:32350255) (PMCID:PMC7190642)

Bell, J. D., Harkiss, A. H., Nobis, D., Malcolm, E., Knuhtsen, A., Wellaway, C. R., Jamieson, A. G. , Magennis, S. W. and Sutherland, A. (2020) Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence. Chemical Communications, 56(12), pp. 1887-1890. (doi: 10.1039/C9CC09064A) (PMID:31956866)

Song, Y. et al. (2020) Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex. Cell Reports, 30(8), 2699-2711.e8. (doi: 10.1016/j.celrep.2020.01.091) (PMID:32101746)

2019

Alam, M. M. et al. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365(6456), eaau1682. (doi: 10.1126/science.aau1682) (PMID:31467193)

Mahindra, A., Millard, C. J., Black, I., Archibald, L. J., Schwabe, J. W.R. and Jamieson, A. G. (2019) Synthesis of HDAC substrate peptidomimetic inhibitors (SPIs) using Fmoc amino acids incorporating zinc-binding groups. Organic Letters, 21(9), pp. 3178-3182. (doi: 10.1021/acs.orglett.9b00885) (PMID:30998366) (PMCID:PMC6503537)

Clark, G. C., Casewell, N. R., Elliott, C. T., Harvey, A. L., Jamieson, A. G. , Strong, P. N. and Turner, A. D. (2019) Friends or foes? Emerging impacts of biological toxins. Trends in Biochemical Sciences, 44(4), pp. 365-379. (doi: 10.1016/j.tibs.2018.12.004) (PMID:30651181)

McDougall, L. and Jamieson, A. G. (2019) Stapled peptides as potential therapeutics. In: Encyclopedia of Life Sciences. Wiley: Chichester. ISBN 9780470015902 (doi: 10.1002/9780470015902.a0028403)

Harkiss, A. H., Bell, J. D., Knuhtsen, A., Jamieson, A. G. and Sutherland, A. (2019) Synthesis and fluorescent properties of β-pyridyl α-amino acids. Journal of Organic Chemistry, 84(5), pp. 2879-2890. (doi: 10.1021/acs.joc.9b00036) (PMID:30726078)

Knuhtsen, A., Whitmore, C., McWhinnie, F. S., McDougall, L., Whiting, R., Smith, B. O. , Timperley, C. M., Green, A. C., Kinnear, K. I. and Jamieson, A. G. (2019) α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor. Chemical Science, 10, pp. 1671-1676. (doi: 10.1039/C8SC04198A)

2018

Kelly, R.D.W., Chandru, A., Watson, P.J., Song, Y., Blades, M., Robertson, N.S., Jamieson, A.G. , Schwabe, J.W.R. and Cowley, S.M. (2018) Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Scientific Reports, 8, 14690. (doi: 10.1038/s41598-018-32927-9) (PMID:30279482) (PMCID:PMC6168483)

Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R. and Jamieson, A. G. (2018) Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus. Chemical Communications, 54(22), pp. 2767-2770. (doi: 10.1039/C7CC06093A) (PMID:29484340)

McDougall, L., Draper, E. R. , Beadle, J. D., Shipman, M., Raubo, P., Jamieson, A. G. and Adams, D. (2018) Enzymatically-stable oxetane-based dipeptide hydrogels. Chemical Communications, 54(14), pp. 1793-1796. (doi: 10.1039/C7CC09701H) (PMID:29384155)

2017

Beadle, J. D., Knuhtsen, A., Hoose, A., Raubo, P., Jamieson, A. G. and Shipman, M. (2017) Solid-phase synthesis of oxetane modified peptides. Organic Letters, 19(12), pp. 3303-3306. (doi: 10.1021/acs.orglett.7b01466) (PMID:28585839)

Pacifico, S., Kerckhoffs, A., Fallow, A. J., Foreman, R. E., Guerrini, R., McDonald, J., Lambert, D. G. and Jamieson, A. G. (2017) Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor. Organic and Biomolecular Chemistry, 15(21), pp. 4704-4710. (doi: 10.1039/C7OB00959C) (PMID:28524918)

2016

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. , Potter, B. V.L. and Schwabe, J. W.R. (2016) Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nature Communications, 7, 11262. (doi: 10.1038/ncomms11262) (PMID:27109927) (PMCID:PMC4848466)

Burton, M. J. et al. (2016) A heme-binding domain controls regulation of ATP-dependent potassium channels. Proceedings of the National Academy of Sciences of the United States of America, 113(14), pp. 3785-3790. (doi: 10.1073/pnas.1600211113) (PMID:27006498) (PMCID:PMC4833257)

Rennie, Y. K., McIntyre, P. J., Akindele, T., Bayliss, R. and Jamieson, A. (2016) A TPX2 proteomimetic has enhanced affinity for Aurora-A due to hydrocarbon stapling of a helix. ACS Chemical Biology, 11(12), pp. 3383-3390. (doi: 10.1021/acschembio.6b00727) (PMID:27775325)

2015

Jamieson, A. and Robertson, N. (2015) Regulation of protein–protein interactions using stapled peptides. Reports in Organic Chemistry, 2015(5), pp. 65-74. (doi: 10.2147/ROC.S68161)

Hudson, G. M., Watson, P. J., Fairall, L., Jamieson, A. G. and Schwabe, J. W.R. (2015) Insights into the recruitment of class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR transcriptional repression complex. Journal of Biological Chemistry, 290(29), pp. 18237-18244. (doi: 10.1074/jbc.M115.661058) (PMID:26055705) (PMCID:PMC4505066)

2014

Aillard, B., Robertson, N. S., Baldwin, A. R., Robins, S. and Jamieson, A. G. (2014) Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides. Organic and Biomolecular Chemistry, 12(43), pp. 8775-8782. (doi: 10.1039/C4OB01832J) (PMID:25266495)

Evans, S. E., Goult, B. T., Fairall, L., Jamieson, A. G. , Ko Ferrigno, P., Ford, R., Schwabe, J. W.R. and Wagner, S. D. (2014) The ansamycin antibiotic, Rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. PLoS ONE, 9(3), e90889. (doi: 10.1371/journal.pone.0090889) (PMID:24595451) (PMCID:PMC3942486)

2013

Jamieson, A. G. , Boutard, N., Sabatino, D. and Lubell, W. D. (2013) Peptide scanning for studying structure-activity relationships in drug discovery. Chemical Biology and Drug Design, 81(1), pp. 148-165. (doi: 10.1111/cbdd.12042) (PMID:23253136)

2012

Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G. , Hartley, R. C. and Stone, T. W. (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Jamieson, A. G. , Russell, D. and Hamilton, A. D. (2012) A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications, 48(31), pp. 3709-3711. (doi: 10.1039/C2CC30295K) (PMID:22399148)

2011

Adler, M. J., Jamieson, A. G. and Hamilton, A. D. (2011) Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. In: Vassilev, L. and Fry, D. (eds.) Small-Molecule Inhibitors of Protein-Protein Interactions. Series: Current topics in microbiology and immunology, 348 (348). Springer, pp. 1-23. ISBN 9783642170829 (doi: 10.1007/82_2010_91)

2010

Ronga, L., Jamieson, A. G. , Beauregard, K., Quiniou, C., Chemtob, S. and Lubell, W. D. (2010) Insertion of multiple α-amino γ-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns. Biopolymers, 94(2), pp. 183-191. (doi: 10.1002/bip.21288)

Boutard, N., Jamieson, A. G. , Ong, H. and Lubell, W. D. (2010) Structure-activity analysis of the growth hormone Secretagogue GHRP-6 by α- and β-amino γ-lactam positional scanning. Chemical Biology and Drug Design, 75(1), pp. 40-50. (doi: 10.1111/j.1747-0285.2009.00913.x)

St-Cyr, D. J., Jamieson, A. G. and Lubell, W. D. (2010) α-Amino-β-hydroxy-γ-lactam for constraining peptide Ser and Thr residue conformation. Organic Letters, 12(8), pp. 1652-1655. (doi: 10.1021/ol1000582)

2009

Bourguet, C. B. et al. (2009) Portraits of the pioneers of the American Peptide Society. In: Del Valle, S., Escher, E. and Lubell, W. D. (eds.) Peptides for Youth. Series: Advances in experimental medicine and biology (611). Springer, xlix-lxix. ISBN 9780387736563

Jamieson, A. G. , Boutard, N., Beauregard, K., Bodas, M. S., Ong, H., Quiniou, C., Chemtob, S. and Lubell, W. D. (2009) Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides. Journal of the American Chemical Society, 131(22), pp. 7917-7927. (doi: 10.1021/ja9010628) (PMID:19453183)

2007

Jamieson, A. G. and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63, pp. 2123-2131. (doi: 10.1016/j.tet.2006.12.067)

Jamieson, A. G. and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9, pp. 1609-1611. (doi: 10.1021/ol070424z) (PMID:17371038)

2006

Fanning, K. N., Jamieson, A. G. and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10(9), pp. 1007-1020. (doi: 10.2174/138527206777435490)

Jamieson, A. G. and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4, pp. 2932-2937. (doi: 10.1039/b607014k) (PMID:16855742)

2005

Fanning, K. N., Jamieson, A. G. and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 3749-3756. (doi: 10.1039/b510808j) (PMID:16211111)

Jamieson, A. G. and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 735-736. (PMID:15731857)

2004

Jamieson, A. G. , Sutherland, A. and Willis, C. L. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2, pp. 808-809. (doi: 10.1039/b401076k)

This list was generated on Thu Nov 21 17:59:55 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 48.

Articles

Brettell, S. B. et al. (2024) Targeting PfCLK3 with covalent inhibitors: a novel strategy for malaria treatment. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01300) (PMID:39441986) (Early Online Publication)

McGrory, R., Morgan, D. C., Jamieson, A. G. and Sutherland, A. (2023) Rotamer-controlled dual emissive α-amino acids. Organic Letters, 25(31), pp. 5844-5849. (doi: 10.1021/acs.orglett.3c02112) (PMID:37506290) (PMCID:PMC10425982)

Morgan, D. C., McDougall, L., Knuhtsen, A. and Jamieson, A. G. (2023) Development of bifunctional, Raman active diyne‐girder stapled α‐helical peptides. Chemistry: A European Journal, 29(41), e202300855. (doi: 10.1002/chem.202300855) (PMID:37130830)

Archibald, L. J., Brown, E. A., Millard, C. J., Watson, P. J., Robertson, N. S., Wang, S., Schwabe, J. W. R. and Jamieson, A. G. (2022) Hydroxamic acid-modified peptide library provides insights into the molecular basis for the substrate selectivity of HDAC corepressor complexes. ACS Chemical Biology, 17(9), pp. 2572-2582. (doi: 10.1021/acschembio.2c00510) (PMID:35973051) (PMCID:PMC9488896)

Mahindra, A. et al. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists. Journal of Medicinal Chemistry, 65(16), pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804) (PMID:35948061) (PMCID:PMC9421653)

Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)

Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)

Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)

Knuhtsen, A., Whiting, R., McWhinnie, F. S., Whitmore, C., Smith, B. O. , Green, A. C., Timperley, C. M., Kinnear, K. I. and Jamieson, A. G. (2021) μ-conotoxin KIIIA peptidomimetics that block human voltage-gated sodium channels. Peptide Science, 113(1), e24203. (doi: 10.1002/pep2.24203)

Mahindra, A., Janha, O., Mapesa, K., Sanchez Azqueta, A., Alam, M. M. , Amambua-Ngwa, A., Nwakanma, D. C., Tobin, A. B. and Jamieson, A. G. (2020) Development of potent PfCLK3 inhibitors based on TCMDC-135051 as a new class of antimalarials. Journal of Medicinal Chemistry, 63(17), pp. 9300-9315. (doi: 10.1021/acs.jmedchem.0c00451) (PMID:32787140) (PMCID:PMC7497403)

Minard, A., Morgan, D., Raguseo, F., Di Porzio, A., Liano, D., Jamieson, A. G. and Di Antonio, M. (2020) A short peptide that preferentially binds c-MYC G-quadruplex DNA. Chemical Communications, 56(63), pp. 8940-8943. (doi: 10.1039/D0CC02954H) (PMID:32638724)

Magnussen, H. M. et al. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications, 11, 2094. (doi: 10.1038/s41467-020-15783-y) (PMID:32350255) (PMCID:PMC7190642)

Bell, J. D., Harkiss, A. H., Nobis, D., Malcolm, E., Knuhtsen, A., Wellaway, C. R., Jamieson, A. G. , Magennis, S. W. and Sutherland, A. (2020) Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence. Chemical Communications, 56(12), pp. 1887-1890. (doi: 10.1039/C9CC09064A) (PMID:31956866)

Song, Y. et al. (2020) Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex. Cell Reports, 30(8), 2699-2711.e8. (doi: 10.1016/j.celrep.2020.01.091) (PMID:32101746)

Alam, M. M. et al. (2019) Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science, 365(6456), eaau1682. (doi: 10.1126/science.aau1682) (PMID:31467193)

Mahindra, A., Millard, C. J., Black, I., Archibald, L. J., Schwabe, J. W.R. and Jamieson, A. G. (2019) Synthesis of HDAC substrate peptidomimetic inhibitors (SPIs) using Fmoc amino acids incorporating zinc-binding groups. Organic Letters, 21(9), pp. 3178-3182. (doi: 10.1021/acs.orglett.9b00885) (PMID:30998366) (PMCID:PMC6503537)

Clark, G. C., Casewell, N. R., Elliott, C. T., Harvey, A. L., Jamieson, A. G. , Strong, P. N. and Turner, A. D. (2019) Friends or foes? Emerging impacts of biological toxins. Trends in Biochemical Sciences, 44(4), pp. 365-379. (doi: 10.1016/j.tibs.2018.12.004) (PMID:30651181)

Harkiss, A. H., Bell, J. D., Knuhtsen, A., Jamieson, A. G. and Sutherland, A. (2019) Synthesis and fluorescent properties of β-pyridyl α-amino acids. Journal of Organic Chemistry, 84(5), pp. 2879-2890. (doi: 10.1021/acs.joc.9b00036) (PMID:30726078)

Knuhtsen, A., Whitmore, C., McWhinnie, F. S., McDougall, L., Whiting, R., Smith, B. O. , Timperley, C. M., Green, A. C., Kinnear, K. I. and Jamieson, A. G. (2019) α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor. Chemical Science, 10, pp. 1671-1676. (doi: 10.1039/C8SC04198A)

Kelly, R.D.W., Chandru, A., Watson, P.J., Song, Y., Blades, M., Robertson, N.S., Jamieson, A.G. , Schwabe, J.W.R. and Cowley, S.M. (2018) Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo. Scientific Reports, 8, 14690. (doi: 10.1038/s41598-018-32927-9) (PMID:30279482) (PMCID:PMC6168483)

Girt, G. C., Mahindra, A., Al Jabri, Z. J.H., De Ste Croix, M., Oggioni, M. R. and Jamieson, A. G. (2018) Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus. Chemical Communications, 54(22), pp. 2767-2770. (doi: 10.1039/C7CC06093A) (PMID:29484340)

McDougall, L., Draper, E. R. , Beadle, J. D., Shipman, M., Raubo, P., Jamieson, A. G. and Adams, D. (2018) Enzymatically-stable oxetane-based dipeptide hydrogels. Chemical Communications, 54(14), pp. 1793-1796. (doi: 10.1039/C7CC09701H) (PMID:29384155)

Beadle, J. D., Knuhtsen, A., Hoose, A., Raubo, P., Jamieson, A. G. and Shipman, M. (2017) Solid-phase synthesis of oxetane modified peptides. Organic Letters, 19(12), pp. 3303-3306. (doi: 10.1021/acs.orglett.7b01466) (PMID:28585839)

Pacifico, S., Kerckhoffs, A., Fallow, A. J., Foreman, R. E., Guerrini, R., McDonald, J., Lambert, D. G. and Jamieson, A. G. (2017) Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor. Organic and Biomolecular Chemistry, 15(21), pp. 4704-4710. (doi: 10.1039/C7OB00959C) (PMID:28524918)

Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. , Potter, B. V.L. and Schwabe, J. W.R. (2016) Insights into the activation mechanism of class I HDAC complexes by inositol phosphates. Nature Communications, 7, 11262. (doi: 10.1038/ncomms11262) (PMID:27109927) (PMCID:PMC4848466)

Burton, M. J. et al. (2016) A heme-binding domain controls regulation of ATP-dependent potassium channels. Proceedings of the National Academy of Sciences of the United States of America, 113(14), pp. 3785-3790. (doi: 10.1073/pnas.1600211113) (PMID:27006498) (PMCID:PMC4833257)

Rennie, Y. K., McIntyre, P. J., Akindele, T., Bayliss, R. and Jamieson, A. (2016) A TPX2 proteomimetic has enhanced affinity for Aurora-A due to hydrocarbon stapling of a helix. ACS Chemical Biology, 11(12), pp. 3383-3390. (doi: 10.1021/acschembio.6b00727) (PMID:27775325)

Jamieson, A. and Robertson, N. (2015) Regulation of protein–protein interactions using stapled peptides. Reports in Organic Chemistry, 2015(5), pp. 65-74. (doi: 10.2147/ROC.S68161)

Hudson, G. M., Watson, P. J., Fairall, L., Jamieson, A. G. and Schwabe, J. W.R. (2015) Insights into the recruitment of class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR transcriptional repression complex. Journal of Biological Chemistry, 290(29), pp. 18237-18244. (doi: 10.1074/jbc.M115.661058) (PMID:26055705) (PMCID:PMC4505066)

Aillard, B., Robertson, N. S., Baldwin, A. R., Robins, S. and Jamieson, A. G. (2014) Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides. Organic and Biomolecular Chemistry, 12(43), pp. 8775-8782. (doi: 10.1039/C4OB01832J) (PMID:25266495)

Evans, S. E., Goult, B. T., Fairall, L., Jamieson, A. G. , Ko Ferrigno, P., Ford, R., Schwabe, J. W.R. and Wagner, S. D. (2014) The ansamycin antibiotic, Rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. PLoS ONE, 9(3), e90889. (doi: 10.1371/journal.pone.0090889) (PMID:24595451) (PMCID:PMC3942486)

Jamieson, A. G. , Boutard, N., Sabatino, D. and Lubell, W. D. (2013) Peptide scanning for studying structure-activity relationships in drug discovery. Chemical Biology and Drug Design, 81(1), pp. 148-165. (doi: 10.1111/cbdd.12042) (PMID:23253136)

Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G. , Hartley, R. C. and Stone, T. W. (2012) A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance. Behavioural Brain Research, 234(2), pp. 184-191. (doi: 10.1016/j.bbr.2012.06.023)

Jamieson, A. G. , Russell, D. and Hamilton, A. D. (2012) A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications, 48(31), pp. 3709-3711. (doi: 10.1039/C2CC30295K) (PMID:22399148)

Ronga, L., Jamieson, A. G. , Beauregard, K., Quiniou, C., Chemtob, S. and Lubell, W. D. (2010) Insertion of multiple α-amino γ-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns. Biopolymers, 94(2), pp. 183-191. (doi: 10.1002/bip.21288)

Boutard, N., Jamieson, A. G. , Ong, H. and Lubell, W. D. (2010) Structure-activity analysis of the growth hormone Secretagogue GHRP-6 by α- and β-amino γ-lactam positional scanning. Chemical Biology and Drug Design, 75(1), pp. 40-50. (doi: 10.1111/j.1747-0285.2009.00913.x)

St-Cyr, D. J., Jamieson, A. G. and Lubell, W. D. (2010) α-Amino-β-hydroxy-γ-lactam for constraining peptide Ser and Thr residue conformation. Organic Letters, 12(8), pp. 1652-1655. (doi: 10.1021/ol1000582)

Jamieson, A. G. , Boutard, N., Beauregard, K., Bodas, M. S., Ong, H., Quiniou, C., Chemtob, S. and Lubell, W. D. (2009) Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides. Journal of the American Chemical Society, 131(22), pp. 7917-7927. (doi: 10.1021/ja9010628) (PMID:19453183)

Jamieson, A. G. and Sutherland, A. (2007) Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect. Tetrahedron, 63, pp. 2123-2131. (doi: 10.1016/j.tet.2006.12.067)

Jamieson, A. G. and Sutherland, A. (2007) Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine. Organic Letters, 9, pp. 1609-1611. (doi: 10.1021/ol070424z) (PMID:17371038)

Fanning, K. N., Jamieson, A. G. and Sutherland, A. (2006) Palladium(II)-catalysed rearrangement reactions. Current Organic Chemistry, 10(9), pp. 1007-1020. (doi: 10.2174/138527206777435490)

Jamieson, A. G. and Sutherland, A. (2006) Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents. Organic and Biomolecular Chemistry, 4, pp. 2932-2937. (doi: 10.1039/b607014k) (PMID:16855742)

Fanning, K. N., Jamieson, A. G. and Sutherland, A. (2005) Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 3749-3756. (doi: 10.1039/b510808j) (PMID:16211111)

Jamieson, A. G. and Sutherland, A. (2005) A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement. Organic and Biomolecular Chemistry, 3, pp. 735-736. (PMID:15731857)

Jamieson, A. G. , Sutherland, A. and Willis, C. L. (2004) The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement. Organic and Biomolecular Chemistry, 2, pp. 808-809. (doi: 10.1039/b401076k)

Book Sections

McDougall, L. and Jamieson, A. G. (2019) Stapled peptides as potential therapeutics. In: Encyclopedia of Life Sciences. Wiley: Chichester. ISBN 9780470015902 (doi: 10.1002/9780470015902.a0028403)

Adler, M. J., Jamieson, A. G. and Hamilton, A. D. (2011) Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. In: Vassilev, L. and Fry, D. (eds.) Small-Molecule Inhibitors of Protein-Protein Interactions. Series: Current topics in microbiology and immunology, 348 (348). Springer, pp. 1-23. ISBN 9783642170829 (doi: 10.1007/82_2010_91)

Bourguet, C. B. et al. (2009) Portraits of the pioneers of the American Peptide Society. In: Del Valle, S., Escher, E. and Lubell, W. D. (eds.) Peptides for Youth. Series: Advances in experimental medicine and biology (611). Springer, xlix-lxix. ISBN 9780387736563

This list was generated on Thu Nov 21 17:59:55 2024 GMT.

Grants

Assessment of chemical synthesis approaches for native conotoxins and conotoxin mimetics 
Defence Science and Technology Laboratory (Dstl) 
2020 -2021
 
Non-proteinogenic Amino Acids and Peptidomimetics
Innovate UK - North by North-West ICURe 
2019
 
Rescuing mitochondria in peril by targeting of a critical antioxidant protein
BBSRC 
2018-2021
 
Substrate Peptidomimetic Inhibitors (SPIs) of the COP9 signalosome 
EPSRC 
2016 - 2019  
 
Assessment of novel approaches to synthesis of native conotoxins and conotoxin mimetics
Defence Science and Technology Laboratory 
2015 -2019
 
DNA templated synthesis of de novo protein beta-motifs
Leverhulme Trust 
2015 - 2017     
 
1,3-Diyne constrained α-helix peptides: New tools for interrogating protein-protein interactions
EPSRC  
2014 - 2015

 

Teaching

Level-1 Organic Chemistry

Level-3 Biotransformations